Max Theiler (1899-1972): Creator of the yellow fever vaccine.
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منابع مشابه
Yellow fever and Max Theiler: the only Nobel Prize for a virus vaccine
In 1951, Max Theiler of the Rockefeller Foundation received the Nobel Prize in Physiology or Medicine for his discovery of an effective vaccine against yellow fever--a discovery first reported in the JEM 70 years ago. This was the first, and so far the only, Nobel Prize given for the development of a virus vaccine. Recently released Nobel archives now reveal how the advances in the yellow fever...
متن کاملThe Yellow Fever Vaccine: A History
After failed attempts at producing bacteria-based vaccines, the discovery of a viral agent causing yellow fever and its isolation in monkeys opened new avenues of research. Subsequent advances were the attenuation of the virus in mice and later in tissue culture; the creation of the seed lot system to avoid spontaneous mutations; the ability to produce the vaccine on a large scale in eggs; and ...
متن کاملThe Use of Yellow Fever Virus Modified by in Vitro Cultivation for Human Immunization
The response of rhesus monkeys to a subcutaneous inoculation with varying amounts of virus modified by prolonged cultivation in vitro has been studied. The tissue components of the medium consisted of chick embryo tissue containing minimal amounts of nervous tissue. The immunity produced in monkeys, as measured by the antibody titer developed, has no relation to the amount of virus inoculated. ...
متن کاملYellow fever vaccine. V. Antibody response in maonkeys inoculated with graded doses of the 17D vaccine.
A dosage equal to or greater than approximately 3.4 Dex (decimal exponent, log(10)) weanling mouse intracerebral 50% lethal dose (LD(50)) was sufficient to elicit a yellow fever antibody response, as determined by the plaque neutralization (PN) test, in better than 90% of vaccinated rhesus monkeys. Lower dosages were progressively less effective in terms of PN titers and the PN and hemagglutina...
متن کاملStudies on bovine ephemeral fever. I. Isolation and preliminary characterization of a virus from natural and experimentally produced cases of bovine ephemeral fever.
Ephemeral fever or thn:.e-day-stiffsickness of cattle has been known for nearly a century, and has been described in East Africa (Schweinfurth, 1867), Rhodesia (Bevan, 1907), South Africa (Theiler, 1908), Indonesia (Merkins, 1919 ; Burggraaf, 1932), India (Meadows, 1919), Japan (Futamara, 1922), Palestine (Rosen, 1931), and Australia (Mulhearn, 1937). During recent years world-wide surveys on t...
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عنوان ژورنال:
- Singapore medical journal
دوره 58 4 شماره
صفحات -
تاریخ انتشار 2017